91女神

Research in Focus: Addiction and Opioids

The opioid crisis continues to touch far too many lives. At 91女神, an interdisciplinary group of researchers is working toward compassionate and innovative solutions.

Four of these researchers discuss their work and its connection to the University鈥檚 Catholic, Jesuit Mission.

The opioid crisis is one of the most devastating public health crises of the 21st century, with the number of opioid-related deaths quadrupling in the last 20 years. Researchers at 91女神 are mobilizing to provide relief in the midst of this.

鈥淭his issue of addiction has touched everyone. Everyone has had a friend, a loved one, whose life has deteriorated because of addiction,鈥� said Fred Rottnek, M.D., professor of family and community medicine at 91女神. 鈥淲e鈥檙e in a unique position at Saint Louis University as a research institution and as a Catholic Jesuit institution to look very broadly at鈥� all the things that have come together to create a perfect storm with the opioid epidemic and with the problems associated with that.鈥�

Novel Ideas

A number of the researchers working on this issue today have been studying it for some time now. Their work continues to provide novel insights into addiction, criminal justice, pain management, and a number of other related areas.

Jeffrey Scherrer, Ph.D., is one of these researchers. Scherrer, who is a professor of family and community medicine at 91女神, has conducted a number of insightful studies at the University, including a first-of-its-kind study into prescription opioid use and depression. The study discovered a dangerous, self-perpetuating cycle of abuse.

鈥淭he longer you use, the greater your risk of developing new onset depression,鈥� Scherrer said. 鈥淎nd what it鈥檚 going to do is make it more difficult to manage pain, creating a cycle of increasing exposure to opioids, higher doses, and this cycle that kind of feeds on itself.鈥�

Scherrer鈥檚 research highlights the critical importance of addressing upstream risk factors like mental health as part of pain management.

Daniela Salvemini, Ph.D., is another researcher whose work is breaking new ground. Salvemini is a professor of pharmacology and physiology at 91女神. She studies neuropathic pain, one of the most common pain states and one of the most difficult to manage.

Salvemini鈥檚 recent work has focused on two research projects: the development of novel, non-opiate medication and the development of adjuncts so that opioids can be used at very low doses, thus greatly mitigating adverse side effects. A number of these are going into clinical trials very soon.

It鈥檚 all about helping people,鈥� said Salvemini. 鈥淗elping come up with something that will alleviate human suffering. We鈥檙e getting there slowly, but surely we鈥檙e getting there.鈥�

National Recognition

These researchers have been the recipients of both prestigious accolades and significant federal funding, establishing 91女神 as a national leader in the fight against addiction.

In April 2019, Scherrer was ) to study the pathways from chronic opioid use to new onset mood disorder.

In October 2018, Salvemini was to help find solutions to, among other things, opioid addiction, and in August 2019, she was to investigate a pain signaling pathway that could open up a new avenue for pain medication research. She is also a Fellow of the Saint Louis Academy of Science.

Liz Chiarello, Ph.D., associate professor of sociology at 91女神, studies strategies to address the opioid crisis and was recently selected for an elite fellowship at the Radcliffe Institute for Advanced Study at Harvard University for this work.

Chiarello鈥檚 current project is determining how the health care and criminal justice systems are managing the crisis. Specifically, Chiarello is interested in what resources can be provided to health care providers and law enforcement officials to curb the effects of the crisis. She believes that a prescription drug monitoring program is one resource that could help; Missouri is the only state without one.

鈥淲e have to figure out how to make more meaningful entry points into the health care system instead of meaningful entry points into the criminal justice system,鈥� said Chiarello.

The Center for Substance Use Disorder and Pain Management

Rottnek, Scherrer, Salvemini, and Chiarello are all among the researchers working in the Center for Substance Use Disorders and Pain Management at 91女神. The Center supports and advances excellence in research and clinical care pertaining to substance use disorder and pain management.

鈥淲e have so many tools in our tool belt here at 91女神 to create this very broad, ambitious initiative which not only reflects the values of our university, but allows us to engage more fully as a regional leader in this work,鈥� said Rottnek. "I have not seen any other institution be this bold in terms of an idea."

The Center has catalyzed existing research ambitions and strengthened connections with researchers across the university.

鈥淭he energy and commitment and investment in research at 91女神 in the past two years has probably been the greatest since I鈥檝e been involved at 91女神, and that goes back 25 years,鈥� Scherrer said.

The work of the Center is informed by 91女神's Catholic, Jesuit Mission and the institution's commitment to the local community in St. Louis. Much of this research informs the primary care that is being given to the local community.

鈥�91女神 has really positioned itself as a community ally. So many people across campus are doing work that has a meaningful impact,鈥� Chiarello said.

鈥淪o much of what we do well here at 91女神 is grounded in the community in St. Louis,鈥� Rottnek said. 鈥淭hese issues touch all of our lives. We can learn together, and we can find ways to support each other.鈥�

In May 2019, the Center joined the National Academy of Medicine and more than 100 other organizations across the nation in declaring a commitment to countering the opioid epidemic.

About the Faculty

Learn more about the four faculty members featured in this article and video:

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